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Target intelligence / Profile preview
Dynactin subunit 4 (DCTN4)
- Target
- DCTN4
- Molecular classification
- Other (multi-protein complex subunit), Microtubule-associated protein
01
Overview
Dynactin subunit 4 (DCTN4, also known as Dyn4 or p62) is a protein encoded by the DCTN4 gene in humans and is a structural subunit of the dynactin complex, which consists of multiple proteins. Dynactin is a key activator of cytoplasmic dynein, the minus-end directed microtubule motor, and is involved in a variety of cellular processes including organelle positioning, vesicle trafficking, and spindle formation during mitosis. The p62/DCTN4 subunit is located at the pointed end of the dynactin Arp1 rod, contributes to the stability of the complex, and is implicated in proper intracellular transport and cargo binding. Genetic variation in DCTN4 is associated with disease modification in cystic fibrosis and has been linked to non-syndromic deafness. In summary, DCTN4 is an essential, structural microtubule-associated protein within the dynactin complex but is not considered a direct receptor or enzyme target for therapeutics.
- Other names
- DCTN4Dyn4p62Dynactin subunit p62DYN4P62dynactin 4 (p62)dynactin p62 subunitdynactin subunit p62
02
Mechanism of action
Not applicable; no direct drug mechanisms described for this subunit
03
Biological functions
Activation of dynein motor activity for intracellular transportCargo binding and traffickingRegulation of microtubule-based transportStability of dynactin complex
04
Disease associations
Cystic fibrosis (modifier of disease severity)Autosomal dominant nonsyndromic deafness 77
05
Safety considerations
No direct safety concerns described for targeting DCTN4 or modulating its expression; therapeutic challenges are associated with the complexity and essential function of the dynactin complex
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