Target intelligence / Profile preview

Dynamin 1 (DNM1)

Target: DNM1
Molecular classification: Enzyme, GTPase

Overview

Dynamin 1 is a large GTPase enzyme that plays a critical role in membrane remodeling events, particularly endocytosis and synaptic vesicle recycling in neurons. It catalyzes GTP hydrolysis to drive membrane fission. Mutations in DNM1 are associated with severe childhood epilepsy.

Mechanism of action

N/A

Biological functions

Clathrin-mediated endocytosisSynaptic vesicle recyclingVesicular traffickingMembrane fission

Disease associations

Developmental and epileptic encephalopathy

Safety considerations

Dominant negative effects of some mutations

Beyond the preview

Go deeper on Dynamin 1 (DNM1).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Dynamin 1 (DNM1).

Explore the full profile