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Dynamin 2 (DNM2)
- Target
- DNM2
- Molecular classification
- Enzyme, GTPase
01
Overview
Dynamin 2 (DNM2) is a large GTPase enzyme ubiquitously expressed in human tissues and encoded by the DNM2 gene. It plays a central role in membrane remodeling processes, especially during endocytosis and actin cytoskeleton organization.
02
Mechanism of action
Dynamin oligomerizes into helical spirals around budding vesicles or tubules, hydrolyzing GTP to provide mechanical force for membrane constriction/scission or filament remodeling.
03
Biological functions
Clathrin-mediated endocytosisVesicular traffickingActin cytoskeleton organizationCentrosome cohesionMembrane remodeling
04
Disease associations
Centronuclear myopathyCharcot-Marie-Tooth disease type 2BAcute lymphoblastic leukemia
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