Drug pipeline
Explore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Dynamin 2 (DNM2)
- Target
- DNM2
- Molecular classification
- Enzyme, GTPase
01
Overview
Dynamin 2 (DNM2) is a large GTPase enzyme ubiquitously expressed in human tissues and encoded by the DNM2 gene. It plays a central role in membrane remodeling processes, especially during endocytosis and actin cytoskeleton organization.
02
Mechanism of action
Dynamin oligomerizes into helical spirals around budding vesicles or tubules, hydrolyzing GTP to provide mechanical force for membrane constriction/scission or filament remodeling.
03
Biological functions
Clathrin-mediated endocytosisVesicular traffickingActin cytoskeleton organizationCentrosome cohesionMembrane remodeling
04
Disease associations
Centronuclear myopathyCharcot-Marie-Tooth disease type 2BAcute lymphoblastic leukemia
Beyond the preview
Go deeper on Dynamin 2 (DNM2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Follow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Compare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Investigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Explore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Connect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Dynamin 2 (DNM2).