Dynamin-binding protein (DNMBP)

Dynamin-binding protein (DNMBP), also known as ARHGEF36, KIAA1010, and Tuba, is a guanine nucleotide exchange factor (GEF) that primarily activates CDC42, a member of the Rho GTPase family[1][2][4]. DNMBP serves as a scaffold protein, facilitating interactions between dynamin and actin regulatory proteins to organize the actin and microtubule cytoskeleton essential for cell structure and signaling[2][7]. It is involved in regulating the structure of apical junctions in epithelial cells through F-actin organization, spindle orientation during lumenogenesis, and possibly ciliogenesis and membrane trafficking[1][2][5]. DNMBP gene polymorphisms have been linked to certain cataract types and may be associated with susceptibility to Alzheimer’s disease in specific populations, though with conflicting evidence[2]. Alternative splicing results in multiple transcript variants for this protein[2]. DNMBP forms part of cellular pathways involving Rho GTPase signaling, essential for cytoskeletal dynamics and cell junction configuration[2][4]. It is considered a molecular target due to its role as a GEF in signaling pathways relevant to disease and cell biology[2][4].

Other names

KIAA1010TubaARHGEF36Scaffold protein TubaCTRCT48ENSG00000107554