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Target intelligence / Profile preview
Dynamin-related protein 1 (Drp1)
- Target
- Drp1
- Molecular classification
- GTPase, Dynamin superfamily
01
Overview
Dynamin-related protein 1 (Drp1) is a large GTPase that plays a central role in mitochondrial fission. It belongs to the dynamin superfamily of proteins and is essential for cellular homeostasis, including mitophagy, mitochondrial distribution, ROS regulation, calcium signaling, and apoptosis. Drp1 dysfunction is implicated in various diseases, including neurodevelopmental disorders, neurodegenerative diseases, and cardiovascular disease.
- Other names
- Dynamin-1-like proteinDVLPDLP1DympleDNM1L
02
Mechanism of action
Drp1 mediates mitochondrial division by assembling into multimeric structures that wrap around constriction points on mitochondria. Upon GTP hydrolysis, these structures constrict and sever the mitochondrial membrane.
03
Biological functions
Mitochondrial fissionMitophagyRegulation of reactive oxygen species (ROS) productionCalcium signalingApoptosis regulation
04
Disease associations
Neurodevelopmental disordersNeurodegenerative diseasesCardiovascular diseaseCancer
05
Safety considerations
Dysfunction can cause abnormal brain development and early mortality.Inhibition may disrupt normal mitochondrial function.
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