Dynein axonemal assembly factor 15 (PIH1D2)

Dynein axonemal assembly factor 15 (PIH1D2) is a member of the PIH1 domain–containing protein family, serving as a co-chaperone/co-factor in the preassembly of axonemal dynein arms, which are essential for the movement of motile cilia[2]. PIH1D2 functions primarily in the cytoplasm and is a component of the R2TP complex, interacting with molecular chaperones such as Hsp90 to assist in the assembly and stabilization of large macromolecular complexes[1]. Its PIH1 domain facilitates phosphorylation-dependent protein-protein interactions, particularly with phosphoserine-containing motifs, and it is implicated in the assembly of ribonucleoprotein particles, RNA polymerase complexes, and chromatin remodeling. In vertebrates, PIH1D2 is required for proper assembly of dynein motors within cilia; loss of function can result in impaired ciliary motility and contribute to disorders such as primary ciliary dyskinesia[2]. Unlike many classical drug targets (e.g., receptors, enzymes), there are currently no known drugs or direct mechanisms of small-molecule action targeting PIH1D2, nor is it established as a selective therapeutic biomarker or a recognized target for pharmaceutical intervention.

Other names

PIH1 domain-containing protein 2PIH1D2DNAAF15PIH1 domain containing 2dynein axonemal assembly factor 15