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Target intelligence / Profile preview
Dynein axonemal assembly factor 19 (DNAAF19)
- Target
- DNAAF19
- Molecular classification
- Other (Axonemal dynein assembly factor), cytoplasmic protein, coiled-coil domain protein
01
Overview
Dynein axonemal assembly factor 19 (DNAAF19), also known as CCDC103, is a cytoplasmic protein required for the assembly of axonemal dynein complexes, which are essential for the motility of cilia. DNAAF19 is a coiled-coil domain-containing protein thought to facilitate protein-protein interactions necessary for proper dynein arm formation and attachment in motile cilia. It plays critical roles in processes such as cilium movement and determination of left-right body symmetry during development. Mutations in DNAAF19 are implicated in primary ciliary dyskinesia—a genetic disorder characterized by impaired ciliary function leading to chronic respiratory tract infections, randomization of organ laterality, and, in some cases, infertility. There are no known drugs that target this protein, and it is not considered a direct therapeutic target.
- Other names
- CCDC103Coiled-coil domain-containing protein 103FLJ13094FLJ34211PR46bCILD17SMH
02
Biological functions
Axonemal dynein complex assemblyCilium movementDetermination of left/right symmetryProtein homodimerizationHeart looping
03
Disease associations
Primary ciliary dyskinesiaLeft/right body asymmetry defectsSitus inversus
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