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Dynein axonemal assembly factor 8 (DNAAF8)
- Target
- DNAAF8
- Molecular classification
- Other (specifically, axonemal assembly factor; not a typical enzyme, receptor, transporter, or ion channel)
01
Overview
Dynein axonemal assembly factor 8 (DNAAF8) is a protein involved in the assembly and deployment of the outer dynein arm (ODA) to the axoneme in ciliated cells. It interacts with components of the dynein complex and is required for proper ciliary motion. Disruption of DNAAF8 function can lead to defects in ciliary movement and is linked to ciliopathies such as primary ciliary dyskinesia[1][7][8].
- Other names
- C16orf71DAAP1FLJ43261DKFZp686H2240Dynein axonemal-associated protein 1uncharacterized protein C16orf71
02
Biological functions
Outer dynein arm assemblyDynein complex binding
03
Disease associations
Other (associated with primary ciliary dyskinesia and related disorders of ciliary motility[1])
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