Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Dynein axonemal assembly factor 9 (DNAAF9)
- Target
- DNAAF9
- Molecular classification
- Other, Cytoplasmic assembly factor
01
Overview
Dynein axonemal assembly factor 9 (DNAAF9) is a protein involved in the assembly and regulation of outer dynein arms (ODAs), key motor complexes essential for ciliary/flagellar movement in motile cilia. DNAAF9 is required for the proper transport, assembly, and activation of these axonemal dynein complexes. Mutations in DNAAF9 are associated with motile ciliopathies manifesting as primary microcephaly and retinitis pigmentosa in humans. DNAAF9 (also known as Shulin or C20orf194) is distinguished by the presence of a C-terminal coiled-coil domain and functions as an effector molecule, potentially interacting with ARL3. It is not currently a recognized therapeutic target (e.g., for pharmacological intervention), but its role in ciliary biology makes it significant in rare genetic disorders related to ciliary function[1][2][4][7].
- Other names
- C20orf194ShulinDKFZp434N061uncharacterized protein C20orf194dynein axonemal assembly factor 9shulin
02
Biological functions
Axonemal dynein assemblyRegulation of transport and activation of outer dynein arms in ciliaPotential effector for ARL3Involved in motile cilia functionCiliary/flagellar movement and structure
03
Disease associations
Primary microcephaly (autosomal recessive)Retinitis pigmentosaCiliary dysfunction (motile ciliopathies, as inferred from its function)Spinocerebellar ataxia region candidate (but currently not a direct disease gene)
04
Safety considerations
Disruption can cause ciliary dysfunction, primary microcephaly, and retinitis pigmentosa due to defective dynein arm assembly and impaired ciliary motility
Beyond the preview
Go deeper on Dynein axonemal assembly factor 9 (DNAAF9).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Dynein axonemal assembly factor 9 (DNAAF9).