Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Dynein axonemal heavy chain 1 (DNAH1)
- Target
- DNAH1
- Molecular classification
- Motor protein, Microtubule-associated protein, Axonemal dynein (inner dynein arm), Cytoskeletal protein
01
Overview
Dynein axonemal heavy chain 1 (DNAH1) is a large motor protein that forms part of the inner dynein arm complex in sperm flagella and motile cilia. It is crucial for generating the force required for flagellar and ciliary motion by hydrolyzing ATP to move along microtubules and supports structural integrity between radial spokes and outer doublet microtubules. Mutations in DNAH1 disrupt the axoneme structure, resulting in multiple morphological abnormalities of sperm flagella (MMAF), asthenozoospermia, and male infertility. DNAH1-related dysfunction also causes primary ciliary dyskinesia in some cases, but patients may present variation based on mutation specifics. DNAH1 is not currently a direct therapeutic target and there are no known small-molecule drugs that modulate its function.
- Other names
- DNAHC1HDHC7HL-11HL11HSRF-1XLHSRF-1SPGF18CILD37Axonemal beta dynein heavy chain 1Ciliary dynein heavy chain 1Heat shock regulated protein 1hDHC7Testicular tissue protein Li 60
02
Biological functions
Sperm flagellum motilityCiliary motion/beatingATP hydrolysisForce generation along microtubulesAxoneme assembly and structural support
03
Disease associations
Primary ciliary dyskinesia (specifically Ciliary Dyskinesia, Primary, 37)Male infertility (esp. due to multiple morphological anomalies of the flagella, MMAF, and asthenozoospermia)Spermatogenic failure 18
04
Safety considerations
Loss of DNAH1 function leads to male infertility, but no reports of therapeutic targeting; not known to be essential for viability in humans, but disruption causes infertility and flagellar/ciliary defects
05
Biomarkers
Loss-of-function mutations in DNAH1 as a diagnostic biomarker for MMAF/male infertilityAbsence of DNAH1 protein in sperm tail (for immunostaining in diagnosis)
Beyond the preview
Go deeper on Dynein axonemal heavy chain 1 (DNAH1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Dynein axonemal heavy chain 1 (DNAH1).