Dynein axonemal heavy chain 10 (DNAH10)

Dynein axonemal heavy chain 10 (DNAH10) is a large, microtubule-associated motor protein that forms part of the inner arm dynein complex in motile cilia and flagella. It functions as an ATPase, converting ATP hydrolysis into mechanical work to generate force toward the minus ends of microtubules within cilia, driving the motility necessary for processes such as sperm flagellar movement and mucociliary clearance in the airways. DNAH10 also plays a role in epithelial cell proliferation, migration, and differentiation, particularly in skin, where its expression correlates with inflammation and barrier function. Mutations or altered activity of DNAH10 are implicated in male infertility due to defective sperm motility, in axonemal/ciliary disorders, and, in animal models, in congenital scoliosis and body axis defects. There are currently no drugs that specifically target DNAH10, nor is it considered a therapeutic target or clinical biomarker.

Other names

Dynein axonemal heavy chain 10DNAH10KIAA2017FLJ43808Axonemal beta dynein heavy chain 10Ciliary dynein heavy chain 10SPGF56dynein heavy chain 10, axonemaldynein, axonemal, heavy polypeptide 10