Dynein axonemal heavy chain 12 (DNAH12)

Dynein axonemal heavy chain 12 (DNAH12) is a large, mammalian-conserved inner dynein arm heavy chain motor protein expressed predominantly in the testes and ciliated tissues including lungs, trachea, and oviducts[1][3]. The protein comprises a N-terminal stem domain crucial for protein-protein interactions and a motor domain with ATPase activity that powers minus-end-directed microtubule movement, essential for sperm motility and flagellar assembly[1][2][3]. DNAH12 interacts with other axonemal dynein components, notably DNALI1 and DNAH1, forming a critical complex for flagellar development and axonemal integrity. Deficiency or mutations in DNAH12 disrupt proper recruitment of interacting components, impair sperm flagella structure, and can result in severe asthenoteratozoospermia or MMAF, manifesting primarily as male infertility but without classic PCD symptoms known for other dynein family members[1][3]. DNAH12 is predicted to lack the microtubule-binding domain present in other dynein heavy chains, marking its unique molecular features within the dynein superfamily[1].

Other names

DHC3DLP12DNAH12LDNAH7LDNAHC3DNHD2HDHC3HL19Dnahc3hdhc3FLJ40427FLJ44290Axonemal beta dynein heavy chain 12Ciliary dynein heavy chain 12Dynein heavy chain domain-containing protein 2axonemal dynein heavy chain isotype3dynein, axonemal, heavy polypeptide 12Dynein, heavy chain-5SPGF100

Not applicable (no drugs known to target this protein directly)