Dynein axonemal heavy chain 2 (DNAH2)

Dynein axonemal heavy chain 2 is a member of the axonemal dynein family of motor proteins, encoded by the DNAH2 gene in humans[2]. It functions as a motor protein whose ATPase activity drives movement along microtubules, generating force for the sliding of microtubules within cilia and flagella. This movement is essential for the proper motility of these organelles, thereby supporting processes such as mucociliary clearance in the airways and sperm motility in reproduction[3][6][5]. Axonemal dyneins form multimeric complexes; DNAH2 is a key heavy chain component, interacting with intermediate and light chains to produce highly regulated bending motions crucial for cellular and organismal physiological functions[5][6][1]. Mutations in DNAH2 have been implicated in primary ciliary dyskinesia and related diseases, presenting with respiratory disorders and reproductive issues[2]. Axonemal dyneins—and dynein axonemal heavy chain 2 specifically—are not considered druggable targets; rather, their dysfunction is clinically relevant in genetic disease diagnostics.

Other names

DNAH2Dynein, axonemal, heavy chain 2

Not applicable; no drugs currently act on this target. General motor function is ATP hydrolysis-driven microtubule movement