Dynein axonemal heavy chain 5 (DNAH5)

Dynein axonemal heavy chain 5 is a large, ATPase-containing motor protein encoded by the DNAH5 gene in humans[1][2][5]. It is a key component of the outer dynein arms in motile cilia, generating the force required for ciliary beating by converting chemical energy from ATP hydrolysis into mechanical work[3][5]. This activity is critical for normal respiratory function, reproductive health, and correct placement of internal organs during embryonic development[1][2]. Dysfunction or mutations in DNAH5 are causative for primary ciliary dyskinesia, which manifests as recurrent respiratory infections, abnormal organ laterality (situs inversus or heterotaxy), and reduced fertility[1][2][5]. The protein’s biochemical mechanism involves cyclic ATP-driven conformational changes that move microtubules within the axoneme, producing wave-like ciliary movement[3][5].

Other names

DNAHC5dynein heavy chain 5dynein, axonemal, heavy chain 5dynein, axonemal, heavy polypeptide 5CILD3HL1KTGNRPCD