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Target intelligence / Profile preview
Dynein axonemal heavy chain 7 (DNAH7)
- Target
- DNAH7
- Molecular classification
- Motor protein, Cytoskeletal protein, ATPase
01
Overview
Dynein axonemal heavy chain 7 is a force-generating ATPase protein that forms part of the inner dynein arm of ciliary axonemes, essential for the beating motion of respiratory cilia and sperm flagella. Mutations in DNAH7 disrupt normal ciliary motility and are associated with primary ciliary dyskinesia, leading to impaired mucociliary clearance and potential respiratory complications. This protein binds to ATP and calcium ions, powers movement towards the microtubule minus-end, and is crucial for ciliary and flagellar function in multiple tissues[1][2][5].
- Other names
- KIAA0944Axonemal beta dynein heavy chain 7Ciliary dynein heavy chain 7Dynein heavy chain-like protein 2hDHC2CILD50
02
Biological functions
Generation of force for ciliary and flagellar movementMicrotubule-based movementATP hydrolysis coupled to movementCalcium ion binding
03
Disease associations
Primary ciliary dyskinesiaBasal ganglia disease
04
Safety considerations
Genetic loss-of-function causes ciliary dyskinesiaPotential infertility due to impaired sperm motility
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