Dynein axonemal intermediate chain 2 (DNAI2)

Dynein axonemal intermediate chain 2 (DNAI2) is a structural protein encoded by the DNAI2 gene, forming a key intermediate chain within the axonemal dynein complex that powers the movement of motile cilia and flagella[1][3]. DNAI2 is essential for the assembly and function of outer dynein arms in respiratory cilia and sperm flagella, underlying its crucial roles in respiratory tract mucociliary clearance and fertility[1][3][5]. Mutations in DNAI2 cause an autosomal recessive disorder known as primary ciliary dyskinesia (CILD9), which manifests as lung disease, male infertility, and, more rarely, female subfertility due to defects in ciliary and flagellar motility[3][5][9]. Studies in mouse and other models support its involvement in both ciliary assembly and gametogenesis. DNAI2 may interact with signaling pathways such as STAT3, influencing tissue-specific proliferation and apoptosis, but it is not considered a classic pharmacological or therapeutic drug target[5].

Other names

CILD9DIC2oda6axonemal dynein intermediate chain 2dynein intermediate chain 2dynein, axonemal, intermediate polypeptide 2