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Target intelligence / Profile preview
Dynein heavy chain domain-containing protein 1 (DNHD1)
- Target
- DNHD1
- Molecular classification
- Microtubule motor protein, Axonemal protein, Coiled-coil domain-containing protein, Other
01
Overview
Dynein heavy chain domain-containing protein 1 (DNHD1) is a microtubule motor protein localizing to the sperm flagellum, where it contributes to the assembly and structural organization of the axoneme, crucial for sperm motility and fertility. Genetic mutations in DNHD1 cause severe flagellar abnormalities—such as disorganization, absence of the central pair complex, and mitochondrial sheath malformation—leading to male infertility with the multiple morphological abnormalities of the sperm flagellum (MMAF) phenotype. DNHD1 has binding activity for dynein intermediate and light chains, supporting its role in assembling flagellar motor complexes. DNHD1 is not currently a recognized therapeutic target, but its mutation status can serve as a genetic biomarker for the diagnosis of certain infertility syndromes.
- Other names
- Dynein heavy chain domain-containing protein 1DNHD1C11orf47CCDC35DHCD1DNHD1LCoiled-coil domain-containing protein 35Dynein heavy chain domain 1-like proteinSPGF65FLJ32752FLJ46184FLJ35709DKFZp686J0796
02
Mechanism of action
Not applicable; no drugs are reported to interact with DNHD1.
03
Biological functions
Assembly of sperm flagellum axonemeMinus-end-directed microtubule motor activity (predicted)Dynein intermediate/light chain bindingEssential for structural integrity of sperm flagellum
04
Disease associations
Spermatogenic failure 65 (SPGF65)Male infertility—multiple morphological abnormalities of the sperm flagellum (MMAF), teratozoospermia
05
Safety considerations
None reported in the therapeutic context, since DNHD1 is not a drug target. Genetic loss-of-function causes male infertility
06
Biomarkers
The detection of DNHD1 mutation or protein absence is a biomarker for MMAF and certain forms of male infertility
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