Dynein light chain roadblock-type 1 (DYNLRB1)

Dynein light chain roadblock-type 1 (DYNLRB1) is a small, non-catalytic accessory subunit of the cytoplasmic dynein 1 motor complex, a multi-protein complex responsible for retrograde transport along microtubules in cells[1][2][3][4]. DYNLRB1 serves as an adaptor, linking specific cargos and regulatory complexes to dynein, and is required for essential cellular processes, including spindle pole integrity during mitosis and long-range organelle and signal transport in neurons[1][2][3]. It is highly conserved and ubiquitously expressed, with knockout or depletion resulting in embryonic lethality and severe neuronal deficits[2]. DYNLRB1 is not an enzyme, receptor, transporter, or ion channel, but its function is crucial for proper dynein-mediated cargo selection and intracellular trafficking across various cell types[1][2][3][4]. It has been implicated in neurodevelopment and possibly neurodegenerative disease due to its essential role in neuronal survival and axonal transport[2]. Key references: - [1] DYNLRB1 maintains mitotic spindle pole integrity and is essential for proper chromosomal segregation. - [2] Conditional knockout models show DYNLRB1 is required for neuronal survival and general dynein-based transport; global knockout is embryonic lethal. - [3] UniProt describes DYNLRB1 as a non-catalytic component of the cytoplasmic dynein complex. - [4] GeneCards highlights its function as a dynein 1 complex accessory protein. There are no known drugs that directly target DYNLRB1, and it is not currently considered a therapeutic target or biomarker.

Other names

Dynein light chain roadblock-type 1DYNLRB1BITHDNCL2ADNLC2AROBLD1HSPC162BLPDynein-associated protein Km23Roadblock domain-containing protein 1Bithoraxoid-like proteinDynein light chain 2A, cytoplasmicdynein, cytoplasmic, light polypeptide 2AROBL/LC7-like 1