Dynein light chain roadblock-type 2 (DYNLRB2)

Dynein light chain roadblock-type 2 (DYNLRB2) is a non-catalytic accessory component of the cytoplasmic dynein 1 complex, which acts as a motor for retrograde transport of vesicles and organelles along microtubules[2][3][6]. DYNLRB2 is specifically upregulated in testis tissue at the protein level and is indispensable for proper spindle formation during male meiosis I, where it helps maintain the integrity of spindle poles by inhibiting pericentriolar material (PCM) fragmentation and recruiting proteins critical for spindle pole function, such as NuMA[1]. DYNLRB2 binds to the dynein intermediate chain and functions in a tissue-specific manner, with its expression mutually exclusive to its paralog DYNLRB1, which is present in somatic, mitotic cells. Dysregulation or loss of DYNLRB2 in mice leads to arrested meiosis and abnormal spindle formation, highlighting its role in cell division. Disease associations include links to certain syndromes and possible use as a cancer biomarker, but no drugs are specifically known to directly target DYNLRB2[1][2].

Other names

Dynein light chain roadblock-type 2DYNLRB2DNCL2BDNLC2BROBLD2Dynein light chain 2B, cytoplasmicRoadblock domain-containing protein 2roadblock domain containing 2bithoraxoid-like proteintesticular tissue protein Li 53