Dynein light chain Tctex-type 2B (DYNLT2B)

Dynein light chain Tctex-type 2B (DYNLT2B) is a non-catalytic accessory protein that forms part of the cytoplasmic dynein-2 complex, a multi-subunit microtubule motor responsible for retrograde intraflagellar transport (IFT) in cilia and flagella[4][5]. In the dynein-2 complex, DYNLT2B serves as a unique Tctex-type light chain, interacting with specific intermediate chains such as WDR34 and WDR60 to ensure proper complex assembly and function[1][3]. DYNLT2B is essential for the movement of cargos from the ciliary tip toward the base and thus plays a vital role in ciliary and flagellar function. Mutations in DYNLT2B are associated with ciliopathies, most notably short-rib thoracic dysplasia 17 with or without polydactyly, a severe congenital disorder affecting skeletal and lung development[5]. There is currently no established therapeutic targeting or drug interaction for this protein, and its primary significance lies in its structural and transport functions within the dynein-2 motor complex[2][3][5].

Other names

Dynein light chain Tctex-type protein 2BTctex1 domain-containing protein 2TCTEX1D2MGC33212SRTD17Tctex1 domain containing 2