Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Dynein light chain Tctex-type protein 2 (DYNLT2)
- Target
- DYNLT2
- Molecular classification
- Dynein light chain, Tctex-type subfamily of dynein light chains, Axonemal dynein accessory protein
01
Overview
Dynein light chain Tctex-type protein 2 (DYNLT2) is a small accessory subunit belonging to the Tctex family of dynein light chains, expressed across multiple tissues including the cytosol and especially the sperm flagellum. It serves as an accessory component of axonemal dynein and may also be present in cytoplasmic dynein 1 complexes, facilitating binding with dynein intermediate chains and supporting microtubule-based traffic, essential for normal cellular transport mechanisms and ciliary/flagellar motility. There is suggestive evidence for involvement in male fertility and associations with congenital diaphragmatic disease, but no established therapeutic interventions, biomarker roles, or explicit safety/targeting data.
- Other names
- TCTE3TCTEX1D3Tcte-3TCTEX2Tctex4oda12T-complex testis-specific protein 3T-complex-associated testis-expressed protein 3Tctex1 domain-containing protein 3Tctex1 domain containing 3
02
Biological functions
Microtubule-based movementAxonemal dynein assembly and functionIntracellular transport (as part of dynein complex)Sperm flagellum motility (potential role inferred from expression and related studies)
03
Disease associations
Male sterility (candidate association by similarity)Diaphragm disease; Congenital diaphragmatic hernia (gene association, but mechanism not defined)
Beyond the preview
Go deeper on Dynein light chain Tctex-type protein 2 (DYNLT2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Dynein light chain Tctex-type protein 2 (DYNLT2).