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Dynein regulatory complex subunit 11 (DRC11)
- Target
- DRC11
- Molecular classification
- Structural protein, Axonemal protein, Cilia/flagella-associated protein, Component of nexin-dynein regulatory complex (N-DRC), Other (not an enzyme, receptor, ion channel, transcription factor, etc.)
01
Overview
Dynein regulatory complex subunit 11 (DRC11) is a structural and regulatory protein in the nexin–dynein regulatory complex (N-DRC), an essential macromolecular assembly in motile cilia and flagella[3]. DRC11 contains a calmodulin-binding motif and an AAA domain, suggesting roles in calcium-mediated signaling and ATP-dependent structural rearrangements. DRC11, together with DRC8, forms a subcomplex in the proximal lobe of the N-DRC linker domain, facilitating contacts to the neighboring B-tubule and modulating ciliary bending and beat regulation[3][1]. Loss of DRC11 disrupts assembly of DRC8, destabilizes N-DRC structure, and reduces ciliary motility, with implicated roles in clinical ciliopathies such as primary ciliary dyskinesia. DRC11 is not an enzyme, receptor, ion channel, or transporter, but is integral to the architecture and dynamics of axonemal microtubules[3].
- Other names
- Dynein regulatory complex protein 11IQCA1IQCAFLJ22527IQ and AAA domain-containing protein 14930465P12RikIQ motif containing with AAA domain 1DRC11
02
Mechanism of action
Not applicable; there are no drugs known to act on DRC11.
03
Biological functions
Regulation of ciliary and flagellar motilityStructural linking of doublet microtubules in axonemal coreCoordination and modulation of dynein motor activity in motile ciliaAssembly of N-DRC subcomplexes (specifically formation of stable contacts to neighboring microtubule via DRC8/DRC11 pairing)Possible role in calcium regulation via calmodulin-binding motifPotential for nucleotide-sensitive conformational changes via AAA domain
04
Disease associations
Primary ciliary dyskinesia (PCD) and related ciliopathies (motile cilia defects may arise from mutations in DRC subunits)Other: Defective flagellar motility may contribute to sperm motility disorders, but direct disease associations specific to DRC11 are not yet well established
05
Safety considerations
None reported specific to DRC11 as a therapeutic target, since it is not targeted by drugs.Loss-of-function mutations may lead to ciliary dysfunction and associated diseases.
06
Biomarkers
Mutational analysis of DRC11 may serve as a diagnostic marker for certain ciliary motility disorders (primary ciliary dyskinesia)Functional assays of ciliary motility (where DRC11 mutations are implicated)
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