Dynein regulatory complex subunit 11 like (DRC11L)

Dynein regulatory complex subunit 11 like (DRC11L) is a protein-coding gene that belongs to a poorly characterized class of proteins containing IQ motifs and AAA (ATPases Associated with diverse cellular Activities) domains. It is predicted to have ATP hydrolysis and microtubule-severing ATPase activities and is involved in microtubule cytoskeleton organization. Clinical associations (predicted, not firmly established) include infantile hypophosphatasia and SAPHO syndrome. DRC11L is not currently recognized as a direct therapeutic target, and validated drugs or biomarker roles have not been described. Nomenclature ambiguity and limited functional data suggest that the knowledge about this target is incomplete and potentially contains pseudogene annotations or confounding aliases[3]. Key issues: DRC11L refers to a predicted/poorly characterized gene/protein, with confounding aliases and references to pseudogenes. There is no evidence that this is a validated therapeutic target or that it is commonly targeted in drug discovery. The function and clinical significance are predicted/computational and not deeply experimentally validated[3]. If highly structured, validated information is needed for drug development or biomarker studies, the incompleteness and the pseudogene status of some aliases indicate that caution is required in using this target.

Other names

IQ and AAA domain-containing protein 1-likeIQCA1LIQCA1P1TCAG_9762IQ and AAA domain-containing protein 1 pseudogene 1IQ motif containing with AAA domain 1 likeIQ motif containing with AAA domain 1-like proteinputative IQ and AAA domain-containing protein 1 pseudogene 1putative IQ motif containing with AAA domain 1 pseudogene 1DRC11L