Dynein regulatory complex subunit 2 (DRC2)

Dynein regulatory complex subunit 2 (DRC2), also known as coiled-coil domain-containing protein 65 (CCDC65), is a protein component of the nexin-dynein regulatory complex (N-DRC), which plays a pivotal role in the regulation of ciliary and flagellar motility. DRC2 forms a structural scaffold with DRC1 to anchor the N-DRC to the A-tubule of axonemal doublet microtubules and mediate interactions with other regulatory structures, including dynein arms and radial spokes. Mutations in DRC2 disrupt the assembly and stability of the N-DRC and related motility complexes, leading to impaired ciliary movement and the clinical syndrome primary ciliary dyskinesia, characterized by chronic respiratory tract infections and other features of dysfunctional motile cilia. DRC2 is not currently considered a therapeutic target or druggable receptor but is important for understanding ciliary biology and related genetic diseases[1][2].

Other names

Coiled-coil domain-containing protein 65CCDC65NYD-SP28FLJ35732FAP250CFAP250CILD27Testis development protein NYD-SP28