Dynein regulatory complex subunit 7 (DRC7)

Dynein regulatory complex subunit 7 (DRC7) is a critical structural subunit of the nexin–dynein regulatory complex (N-DRC), a multi-protein assembly bridging adjacent doublet microtubules within the axoneme of motile cilia and flagella[1][3][4][6][7]. DRC7, the largest N-DRC component (~177 kDa), contains a highly conserved transglutaminase-like domain that likely interacts with glutamylated proteins in the microtubule cytoskeleton[2]. Its primary roles are maintaining the alignment and integrity of axonemal microtubule doublets, stabilizing the axonemal core, and regulating dynein-driven ciliary and flagellar movement. DRC7 is vital for proper sperm flagellum assembly, with knockout models in mice showing disorganized axonemes, immotile sperm, and infertility[1][5]. Deficiencies or mutations in DRC7 disrupt ciliary motility and structural integrity, implicating this protein in genetic forms of ciliopathies and reproductive failure, although DRC7 itself is not currently a therapeutic or diagnostic target in clinical medicine.

Other names

CCDC135CFAP50FAP50C16orf50Coiled-coil domain-containing protein 135Coiled-coil domain-containing protein lobo homolog

Not applicable. DRC7 is not a therapeutic drug target.