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Target intelligence / Profile preview
Dynein regulatory complex subunit 9 (DRC9)
- Target
- DRC9
- Molecular classification
- Other (component of axonemal structural complex)
01
Overview
Dynein regulatory complex subunit 9 (DRC9) is a protein component of the nexin–dynein regulatory complex (N-DRC) found in motile cilia and flagella. The N-DRC acts as a structural and regulatory linker that coordinates dynein motor activity, helping to regulate the beating and structural integrity of the axoneme, particularly in sperm and other motile ciliated cells[1][2][4][5]. DRC9 is predicted to be involved in sperm axoneme assembly, participates in calmodulin and Hsp70 protein interactions, and is required for proper ciliary and flagellar motility, impacting various cellular processes reliant on these microtubule-based organelles[5]. It is not currently considered a direct drug target or receptor, but its function is essential for normal function of motile cilia, and its disruption may contribute to ciliary dyskinesia or flagellar dysfunction[4][5].
- Other names
- IQ domain-containing protein GIQ motif containing GIQCGCFAP122DKFZp434B227
02
Biological functions
Regulation of ciliary motilitySperm axoneme assemblyCalmodulin bindingHsp70 protein binding
03
Disease associations
Other (dysfunction can result in ciliary motility disorders and may be linked to Diamond-Blackfan Anemia)
04
Safety considerations
Dysfunction in this gene may disrupt ciliary motility, but no direct therapeutic or drug-related safety concerns are described[5].
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