Target intelligence / Profile preview

Dysbindin domain-containing protein 1 (DBNDD1)

Target: DBNDD1
Molecular classification: Other (Intrinsically disordered protein), Cytoplasmic protein

Overview

Dysbindin domain-containing protein 1 (DBNDD1) is an evolutionarily conserved, intrinsically disordered cytoplasmic protein expressed in many tissues, including neuronal cells, but lacking expression in ovary, adipose tissue, and bone marrow. Its structure confers potential for regulatory protein-protein interactions. Functionally, DBNDD1 is predicted to play a role in the regulation of signal transduction, but its precise physiological roles remain unclear. Genetic studies highlight DBNDD1 as a candidate susceptibility locus for melanoma, with additional evidence implicating it in neurodegenerative disease models, suggesting involvement in mitochondrial or synaptic stress responses. No direct evidence currently supports its use as a therapeutic target, biomarker, or drug interaction point.

Other names: Dysbindin domain containing 1DBNDD1MGC3101FLJ12582DBND1_HUMAN (UniProt)

Biological functions

Regulation of signal transduction (predicted)Protein–protein interactions (predicted, due to disordered structure)Possible roles in stress response and mitochondrial/synaptic regulation (implicated by proteomic studies in disease models)

Disease associations

Cancer (genetic association with melanoma susceptibility)Neurodegenerative disease (implicated in proteomic analyses in Parkinson’s disease models)Other (general marker in studies of genetic diversity and disease susceptibility)

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