Adeno-associated virus receptor (KIAA0319L) (AAVR)

The Adeno-associated virus receptor (AAVR), encoded by the KIAA0319L gene, is a critical host cell surface protein required for the infection of most adeno-associated virus (AAV) serotypes, including AAV1, AAV2, AAV5, AAV8, and AAV9. It is a transmembrane glycoprotein that functions as a universal entry factor by binding to the AAV capsid and facilitating its trafficking from the plasma membrane through the endosomal system to the trans-Golgi network. While its endogenous biological role is linked to cell adhesion and potentially neuronal migration, its primary significance in biotechnology is as the essential gateway for AAV-based gene therapy vectors. The interaction between the AAV capsid and specific domains (PKD domains) of AAVR determines the efficiency of viral entry and subsequent transgene expression. Understanding AAVR is vital for optimizing gene delivery, as its expression levels across different tissues can influence the tropism and therapeutic efficacy of AAV-delivered genetic medicines.

Other names

KIAA0319-like proteinAAV receptorKIAA0319LAAV-RDyslexia-associated protein KIAA0319-like

The receptor facilitates the binding and internalization of AAV capsids into the host cell via receptor-mediated endocytosis and subsequent trafficking from the cell surface to the Golgi apparatus.