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E-selectin
- Target
- E-selectin
- Molecular classification
- Cell adhesion molecule, Selectin
01
Overview
E-selectin is a cell adhesion molecule exclusively expressed on endothelial cells that plays a crucial role in inflammation and immune cell trafficking. Unlike other selectins, E-selectin expression is primarily induced by inflammatory stimuli rather than being constitutively expressed in most tissues. It mediates the capture and rolling of leukocytes, contributing to inflammatory responses, thrombus formation, and leukocyte activation. Targeting E-selectin holds therapeutic potential in cancer, vascular diseases, and sickle cell disease.
02
Mechanism of action
Blocking E-selectin interactions
03
Biological functions
Leukocyte traffickingInflammatory responseLeukocyte activationCell adhesionImmune cell trafficking
04
Disease associations
CancerVascular diseasesSickle cell diseaseInflammation
05
Interacting drugs
sLeX-conjugated nanoparticles
2 more in the full profile.
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