Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
E-type Prostanoid Receptor 4 (EP4)
- Target
- EP4
- Molecular classification
- G protein-coupled receptor, GPCR, Receptor
01
Overview
EP4 is a G protein-coupled receptor for prostaglandin E2 (PGE2), a key lipid mediator involved in inflammation and various physiological processes. It is considered therapeutically promising due to its broad range of biological effects, including roles in inflammation, vascular function, thrombosis, cancer, and bone metabolism. Its diverse functions are context-dependent, with potential for both beneficial and detrimental effects.
- Other names
- Prostaglandin E2 receptor EP4Prostanoid EP4 receptorPGE2 receptor EP4 subtypePTGER4
02
Mechanism of action
Activation of Gs proteins leading to increased cAMP levels and subsequent activation of PKA, PI3K/AKT/mTOR, and ERK/MAPK pathways; inhibition of NF-kB activation.
03
Biological functions
Signal transductionInflammation modulationVascular tone regulationVasorelaxationAnti-thrombotic propertiesRegulation of cytokine productionBone metabolismGastric acid secretionLipid metabolismCell proliferationCell differentiationCell survivalAngiogenesis
04
Disease associations
InflammationCancerAsthmaMigrainePainTransplant rejectionNon-small-cell lung cancerThrombosis
05
Safety considerations
Tumor-promoting activities under certain conditionsContext-dependent functions
Beyond the preview
Go deeper on E-type Prostanoid Receptor 4 (EP4).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on E-type Prostanoid Receptor 4 (EP4).