Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Histone Acetyltransferase p300 (p300)
- Target
- p300
- Molecular classification
- Enzyme, Histone modification, Transcription factor, Acetyltransferase
01
Overview
p300 is a transcriptional coactivator with histone acetyltransferase (HAT) activity. It regulates gene expression by acetylating lysine residues on histones and non-histone proteins, leading to chromatin remodeling and increased accessibility of DNA for transcription. It plays a crucial role in cell growth, differentiation, and tumor suppression. Mutations or dysregulation of EP300 are linked to developmental disorders and cancer. Small-molecule inhibitors targeting its HAT domain are being explored for therapeutic use.
- Other names
- EP300E1A-associated protein p300KAT3B
02
Mechanism of action
Acetylation of histone and non-histone proteins
03
Biological functions
Transcription activationChromatin remodelingCell growth and divisionCellular differentiationGene regulation
04
Disease associations
CancerDevelopmental disorders
05
Safety considerations
Aberrant expression can contribute to tumorigenesis.Inhibition may affect multiple cellular processes.
06
Interacting drugs
TTK21
1 more in the full profile.
Beyond the preview
Go deeper on Histone Acetyltransferase p300 (p300).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Histone Acetyltransferase p300 (p300).