Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
E1A binding protein p300 (p300)
- Target
- p300
- Molecular classification
- Enzyme, Histone acetyltransferase, Transcription factor, Transcriptional coactivator
01
Overview
E1A binding protein p300 (p300) is a multifunctional nuclear protein encoded by the EP300 gene in humans. It acts primarily as a transcriptional coactivator and histone acetyltransferase (HAT), playing critical roles in regulating gene expression, cell growth, differentiation, and tumor suppression. It interacts with numerous proteins and is involved in several key pathways, including cAMP signaling, hypoxia response, and tumor suppression. Mutations or dysregulation are linked to diseases like Rubinstein-Taybi syndrome and cancer.
- Other names
- Histone acetyltransferase p300KAT3BRSTS2
02
Mechanism of action
Histone acetylation leading to chromatin remodeling and altered gene expression.
03
Biological functions
Transcriptional coactivationHistone acetylationRegulation of cell proliferationRegulation of differentiationRegulation of apoptosisChromatin remodelingRegulation of gene expression
04
Disease associations
Rubinstein-Taybi syndrome type 2 (RSTS2)Menke-Hennekam syndrome 2CancerDevelopmental disorders
05
Safety considerations
Aberrant activity implicated in various cancers.Loss-of-function mutations cause developmental syndromes.
Beyond the preview
Go deeper on E1A binding protein p300 (p300).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on E1A binding protein p300 (p300).