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E1A Binding Protein p300 Bromodomain (p300 Bromodomain)
- Target
- p300 Bromodomain
- Molecular classification
- Bromodomain, Epigenetic reader, Histone acetyltransferase (HAT) domain
01
Overview
The p300 bromodomain is a protein module within the E1A binding protein p300 (EP300) that recognizes and binds to acetylated lysine residues on histones. This interaction facilitates the recruitment of other regulatory proteins and modulates gene transcription by influencing chromatin structure and accessibility. As a key epigenetic reader, the p300 bromodomain is considered a promising therapeutic target, particularly in cancer, where its dysregulation contributes to aberrant gene expression patterns.
- Other names
- EP300 BromodomainCBP/p300 Bromodomain
02
Mechanism of action
Bromodomain inhibitors disrupt the interaction between p300 and acetylated histones, preventing proper gene regulation.
03
Biological functions
Chromatin remodelingTranscriptional coactivationHistone acetylationGene expression regulation
04
Disease associations
CancerDevelopmental disorders
05
Safety considerations
Potential for off-target effects due to bromodomain conservation across different proteins.Inhibition of catalytic activity may block formation of induced pluripotent stem cells.
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