E2F-associated phosphoprotein (EAPP)

E2F-associated phosphoprotein (EAPP) is a nuclear phosphoprotein that interacts with the activating members of the E2F transcription factor family (E2F-1, E2F-2, E2F-3) to regulate cell cycle–related and stress-responsive gene transcription[1][4][7]. EAPP is highly phosphorylated, present throughout the cell cycle except mitosis, and broadly expressed in human tissues[1][6][7][10]. It modulates E2F-dependent transcription, promotes S-phase entry and proliferation, and can stimulate p21 expression, conferring resistance to DNA damage-induced apoptosis in a manner independent of p53 and dependent on p21 expression[4][7]. Elevated EAPP is seen in transformed (cancer) cell lines, and it may contribute to malignant transformation and multidrug resistance by upregulating the MDR1 promoter[1][7]. Unlike classic therapeutic targets such as receptors, enzymes, or transporters, EAPP functions as a cofactor modulator, and no approved drugs directly target EAPP as of current knowledge[1][7][10].

Other names

C14orf11BM-036BM036FLJ20578ENSG00000129518