E2F transcription factor 7 (E2F7)

E2F transcription factor 7 (E2F7) is an atypical member of the E2F family of transcription factors that primarily functions as a transcriptional repressor of cell cycle progression and DNA repair genes[1][3][4][6]. Unlike canonical E2F proteins, E2F7 contains two distinct DNA-binding domains and binds DNA independently of DP co-factors, preferentially associating with a subset of E2F-responsive gene promoters. It regulates transcription by directly repressing genes required for cell cycle transition (notably at G1/S), DNA replication, and DNA repair, thus integrating cell cycle control with the DNA damage response and maintenance of genomic integrity[4][5]. E2F7 also plays roles in angiogenesis and cellular polyploidization. Its aberrant expression or activity can contribute to oncogenesis, as it modulates pathways implicated in cancer and cell survival[1][4][5][6]. No drugs are currently known to specifically target E2F7.

Other names

E2F7E2F-7transcription factor E2F7

Transcriptional repression of E2F target genes via direct DNA binding; inhibition of cell cycle progression; repression of DNA repair gene expression[1][4][6]