E2F1 mRNA stabilizing long non-coding RNA (EMSLR)

E2F1 mRNA stabilizing long non-coding RNA (EMSLR) is an oncogenic long non-coding RNA directly transcriptionally regulated by both C-MYC and E2F1[1][4][6]. EMSLR associates with the RNA binding protein RALY to stabilize the mRNA of E2F1, a key cell-cycle transcription factor, thereby enhancing E2F1 protein levels[1][4][5]. This lncRNA has been shown to promote G1/S cell cycle progression and tumor cell proliferation[1][4][5]. EMSLR is overexpressed in multiple cancers (lung, breast, colon, bladder), and its functional depletion causes G1 arrest and reduces clonogenicity in cancer cells[1][4]. EMSLR also functions in transcriptional repression of other lncRNAs such as LncPRESS1 through chromatin modification, implying epigenetic regulatory activities[1]. Due to its oncogenic role and specific expression patterns, EMSLR is considered a potential biomarker and a novel therapeutic target in cancer[1][4][5][6].

Other names

EMSBCCE4E2F1 mRNA stabilizing factorBladder cancer Cell Cytoplasm-Enriched abundant transcript 4

Stabilization of E2F1 mRNA via interaction with RNA binding protein RALY, leading to increased E2F1 protein expression and promotion of cell cycle progression and cell proliferation[1][4][5]