E3 SUMO-protein ligase KIAA1586 (KIAA1586)

E3 SUMO-protein ligase KIAA1586 is a protein-coding enzyme that regulates the transfer of SUMO (Small Ubiquitin-like Modifier) proteins to substrates, a post-translational modification implicated in various cellular processes. It acts by enabling UBE2I/UBC9-mediated SUMO2 modification of target proteins. KIAA1586 is primarily classified as an E3 SUMO ligase, and its enzymatic activity contributes to protein sumoylation, impacting protein stability, function, and localization. Genetically, it is located on human chromosome 6 and is implicated in disease via gene fusion events (e.g., with RREB1), suggesting a possible role in oncogenesis. Associations have also been reported with schizophrenia and autism spectrum disorder, but no direct pharmacological targeting is described in current sources[1][3][5][4].

Other names

KIAA1586E3 SUMO-protein transferase KIAA1586KIAA1586 protein