E3 SUMO-protein ligase PIAS4 (PIAS4)

E3 SUMO-protein ligase PIAS4 (PIAS4, also known as PIASy or PIAS-gamma) is an enzyme encoded by the *PIAS4* gene in humans and acts as a member of the PIAS (Protein Inhibitor of Activated STAT) protein family[1]. PIAS4 functions mainly as an E3 ligase for SUMOylation, a post-translational modification critical in regulating protein function, subcellular localization, stability, and interactions[5][1]. It acts as a transcriptional co-regulator for numerous proteins, influencing gene expression by either activating or repressing transcription, and it is a crucial component of the DNA damage response, promoting double-stranded DNA break repair through recruitment and SUMOylation of repair factors such as BRCA1 and TP53BP1[6][5]. PIAS4 is involved in modulating immune responses, notably contributing to intrinsic immune defense against DNA viruses such as herpes simplex virus[3], and plays roles in regulating developmental gene expression programs and maintenance of genomic integrity[2][6]. While PIAS4 itself is not currently a direct drug target, its pivotal roles in cancer, genome stability, and immunity make it of significant biomedical interest.

Other names

PIASyPIAS-gammaPIASGPiasgPIASYProtein inhibitor of activated STAT protein gammaProtein inhibitor of activated STAT protein 4Zinc finger, MIZ-type containing 6ZMIZ6FLJ12419RING-type E3 ubiquitin transferase PIAS4

Not applicable/unknown; no drugs acting directly on PIAS4 are described in current literature.