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E3 Ubiquitin Ligase Cereblon Complex
- Molecular classification
- E3 Ubiquitin Ligase, Enzyme, Protein Complex
01
Overview
The E3 ubiquitin ligase cereblon complex, or CRL4^CRBN complex, is a multi-protein assembly that ubiquitinates substrate proteins, marking them for proteasomal degradation. It regulates protein homeostasis and is involved in development, disease, and drug action. Cereblon acts as a substrate receptor, with its substrate specificity being modulated by drugs like thalidomide and its analogs, which are used to treat multiple myeloma.
- Other names
- CRL4^CRBN complex
02
Mechanism of action
IMiDs bind cereblon, altering its substrate specificity to target non-native substrates for degradation.
03
Biological functions
Substrate-specific polyubiquitinationProtein degradationDevelopmental regulationIon channel modulationDrug response
04
Disease associations
Multiple MyelomaDevelopmental DisordersCancer
05
Safety considerations
TeratogenicityDrug resistance
06
Interacting drugs
Thalidomide
2 more in the full profile.
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