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Target intelligence / Profile preview
E3 Ubiquitin Ligase Recruitment (N/A)
- Target
- N/A
- Molecular classification
- Enzyme complex, Ubiquitin ligase, RING-type E3 ligase, HECT-type E3 ligase, RBR-type E3 ligase
01
Overview
E3 ubiquitin ligase recruitment refers to the mechanism by which E3 ligases are brought into proximity with their substrate proteins to catalyze the transfer of ubiquitin. These ligases determine substrate specificity within the ubiquitylation system and thus control fate decisions for thousands of cellular proteins. Targeting or manipulating recruitment mechanisms offers therapeutic leverage points.
- Other names
- E3 ligase recruitmentUbiquitination recruitment
02
Mechanism of action
Small molecules that hijack E3 ligase recruitment to target specific proteins for degradation.
03
Biological functions
Protein degradationProtein modificationCell cycle regulationApoptosisDNA repairImmune responseHormone signalingStress response
04
Disease associations
CancerNeurodegenerative diseaseImmune disorders
05
Safety considerations
Off-target effects due to promiscuity of E3 ligase interactions.Unintended degradation of essential proteins.
06
Interacting drugs
PROTACs
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