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Target intelligence / Profile preview
E3 ubiquitin-protein ligase CBL-B (Cbl-b)
- Target
- Cbl-b
- Molecular classification
- Enzyme, E3 ubiquitin ligase
01
Overview
Cbl-b is an E3 ubiquitin-protein ligase that plays a central role in the ubiquitination pathway. It negatively regulates immune cell activation, particularly in T cells and B cells, by promoting the degradation of key signaling molecules. Mutations or dysregulation of Cbl-b are associated with autoimmune diseases, and it is being explored as a therapeutic target in cancer immunotherapy to enhance anti-tumor immunity.
- Other names
- CBLBc-Cbl-2RNF56
02
Mechanism of action
Inhibition of E3 ubiquitin ligase activity, preventing ubiquitination and degradation of target proteins. Modulation of immune checkpoints.
03
Biological functions
UbiquitinationProtein degradationNegative regulation of immune cell activationT-cell receptor signaling downregulationB-cell receptor signaling downregulationRegulation of osteoclast activityImmune response
04
Disease associations
Autoimmune diseasesType 1 diabetesCancerOsteoporosis
05
Safety considerations
Potential for immune-related adverse events due to enhanced immune cell activationPotential for off-target effects due to the involvement of Cbl-b in multiple signaling pathways
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