E3 ubiquitin-protein ligase CCNB1IP1 (CCNB1IP1)

E3 ubiquitin-protein ligase CCNB1IP1 (CCNB1IP1) is a member of the E3 ubiquitin ligase family that plays a critical role in cell cycle progression, particularly the regulation of G2/M transition, and is required for the proper formation of crossovers during meiosis[1][2][6]. It functions by mediating ubiquitin-dependent protein modification, thereby marking specific substrates for degradation or regulatory modification. During meiosis, CCNB1IP1 helps ensure accurate chromosome segregation by promoting the formation of crossover sites, interacting with other proteins involved in homologous recombination and DNA repair[1][2][6]. Overexpression of CCNB1IP1 can disrupt the timing of mitosis, illustrating its essential role in cell cycle control[1]. Alterations in its expression or function have been associated with certain cancers, such as Schwannomatosis, and potentially other diseases where cell cycle dysregulation plays a part[1][2].

Other names

CCNB1IP1Cyclin B1 interacting protein 1HEI10C14orf18Human enhancer of invasion 10RING-type E3 ubiquitin transferase CCNB1IP1CIP1

Modulation of protein stability through ubiquitin-mediated proteasomal degradation Limiting factor for chromosomal crossover during meiosis by regulating protein-protein interactions at recombination sites