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Target intelligence / Profile preview
E3 ubiquitin-protein ligase MIB2 (MIB2)
- Target
- MIB2
- Molecular classification
- Enzyme, E3 ubiquitin-protein ligase, RING-type E3 ligase
01
Overview
E3 ubiquitin-protein ligase MIB2 (MIB2) is a RING-type E3 ligase enzyme that mediates the ubiquitination of proteins, notably the Delta ligands of the Notch signaling pathway, leading to their endocytosis and subsequent modulation of Notch signaling. MIB2 is expressed predominantly in adult tissues and has paralogous relationships with MIB1, but may play distinct roles in development and disease. It has been implicated as a suppressor of melanoma invasion and is associated with diseases such as melanoma and left ventricular noncompaction.
- Other names
- SkeletrophinZZANK1ZZZ5Zinc finger ZZ type with ankyrin repeat domain protein 1Zinc finger, ZZ type with ankyrin repeat domain 1Putative NF-kappa-B-activating protein 002NRING-type E3 ubiquitin transferase MIB2Novel zinc finger proteinMind bomb homolog 2Mind bomb E3 ubiquitin protein ligase 2
02
Mechanism of action
Ubiquitin ligase-mediated degradation or regulation of substrate proteins, positive regulation of Delta-mediated Notch signaling through substrate ubiquitination and endocytic trafficking
03
Biological functions
UbiquitinationRegulation of Notch signalingSignal transductionProtein modificationEndocytosis of Delta receptorsCell signalingActin binding
04
Disease associations
Cancer (including melanoma)Left ventricular noncompactionPotential role in melanoma metastasis and other cancers
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