E3 Ubiquitin-Protein Ligase Parkin (Parkin)

E3 Ubiquitin-Protein Ligase Parkin is a key enzyme involved in the ubiquitin-proteasome system and mitochondrial quality control. As an E3 ubiquitin ligase, it facilitates the attachment of ubiquitin to target proteins, marking them for degradation or other cellular processes like mitophagy. Mutations in the PRKN gene, which encodes parkin, are a major cause of early-onset Parkinson's disease, highlighting its critical role in neuronal survival and function.

Other names

PRKNPARK2

Not applicable, target is an enzyme and there are no commonly known drugs that directly target it. Research efforts are underway to develop parkin activators or modulators.