E3 ubiquitin-protein ligase RFWD3 (RFWD3)

E3 ubiquitin-protein ligase RFWD3 is an enzyme that functions as a key regulator of DNA damage response and repair, particularly at stalled replication forks and double-strand breaks. It facilitates ubiquitination of several damage response proteins, including RPA, RAD51, and p53, which is critical for their removal from chromatin and subsequent repair by homologous recombination. RFWD3 is essential for maintaining genomic stability and protecting cells from DNA damage, and mutations in its gene cause Fanconi anemia complementation group W, a disorder marked by bone marrow failure and cancer susceptibility. RFWD3 is considered a promising therapeutic target due to its central role in DNA damage signaling and repair, especially in conditions where DNA repair mechanisms are compromised[1][2][3][4].

Other names

RING finger and WD repeat domain 3RNF201FLJ10520FANCWRING finger and WD repeat domain-containing protein 3RING finger protein 201RING-type E3 ubiquitin transferase RFWD3

Promotion of ubiquitination of target proteins at replication forks or DNA damage sites; Facilitation of removal of RPA and RAD51 to promote homologous recombination and resolution of DNA damage