E3 ubiquitin-protein ligase RNF144B (RNF144B)

E3 ubiquitin-protein ligase RNF144B (RNF144B) is an enzyme that facilitates the transfer of ubiquitin from E2 conjugating enzymes onto substrate proteins, targeting them for proteasomal degradation[3][1]. It plays critical roles in regulating cell-cycle progression, apoptosis, and innate immune responses by controlling the stability of key proteins including p21, p63, TBK1, and IRF3[3][1]. RNF144B is localized primarily on the mitochondrial membrane and acts as both a negative regulator of apoptotic processes and a modulator of immune pathways, particularly as a suppressor of inflammatory signaling through TBK1 and IRF3[1][3][4]. In cancer contexts, RNF144B is associated with tumor growth and may serve as a biomarker due to its preferential stabilization in tumor cells[1]. Additionally, RNF144B influences the proliferation and survival of spermatogonial stem cells, implicating its role in male infertility[1]. RNF144B is thus a multifunctional ubiquitin ligase with significant relevance to cancer biology, immune regulation, and reproduction[1][3][4].

Other names

PIR2P53RFPIBRDC2bA528A10.3IBR domain-containing protein 2p53-inducible RING finger protein

Inhibition or modulation of the E3 ubiquitin ligase activity to prevent degradation of key regulatory proteins (e.g., p53, p21, p63, TBK1, IRF3) Indirect modulation of cell death or proliferation pathways