E3 ubiquitin-protein ligase RNF186 (RNF186)

E3 ubiquitin-protein ligase RNF186 is a membrane-associated RING finger-containing E3 ligase highly expressed in colonic epithelial cells and macrophages[1][4][6]. It plays a critical role in regulating the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress by ubiquitinating target proteins such as ATF6, and is required for optimal assembly of pattern recognition receptor (PRR)-induced signaling complexes, including NOD2 signaling pathways[1][2][4]. RNF186 is key to balancing cytokine secretion, cell survival, and antimicrobial mechanisms in innate immunity and epithelial tissues. Genetic variants in RNF186 are linked with increased risk for the development of inflammatory bowel diseases, particularly ulcerative colitis[1][2][4][6]. No approved therapeutics directly target RNF186, but its variants are functionally relevant as biomarkers of disease susceptibility and innate immune dysregulation.

Other names

Ring finger protein 186RNF186FLJ20225hypothetical protein FLJ20225E3 ubiquitin-protein ligase RNF186

Drugs or modulators, if developed, would likely act through modulation of ubiquitin ligase activity to affect ER stress response, protein homeostasis, and inflammatory signaling pathways