Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
E7 Protein of Human Papillomavirus Type 6 (HPV6 E7)
- Target
- HPV6 E7
- Molecular classification
- Viral protein, Oncoprotein, Transcription factor regulator
01
Overview
The E7 protein of human papillomavirus type 6 (HPV6) is a small oncoprotein that plays a crucial role in the viral life cycle. It primarily functions by disrupting the retinoblastoma protein (pRb)-E2F interaction, leading to the activation of E2F transcription factors and subsequent cell cycle progression. Unlike high-risk HPV E7 proteins, HPV6 E7 has lower oncogenic potential and is primarily associated with benign lesions such as genital warts. It is essential for efficient viral genome maintenance within infected cells. Detection of E7 antibodies or mRNA can serve as a biomarker for HPV6 infection.
- Other names
- HPV-6 E7E7 oncoprotein (HPV6)
02
Mechanism of action
Disruption of pRb-E2F complex, leading to uncontrolled cell cycle progression
03
Biological functions
Cell cycle regulationRb protein bindingE2F transcription factor activationViral genome maintenanceCell proliferation
04
Disease associations
InfectionGenital wartsBenign tumorsCervical dysplasia (rare)
05
Safety considerations
Potential for promoting cell proliferationLimited oncogenic potential compared to high-risk HPV types
06
Biomarkers
E7 antibodies (IgG)E7 mRNA expression
Beyond the preview
Go deeper on E7 Protein of Human Papillomavirus Type 6 (HPV6 E7).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on E7 Protein of Human Papillomavirus Type 6 (HPV6 E7).