E74 like ETS transcription factor 4 (ELF4)

E74 like ETS transcription factor 4 (ELF4) is a member of the ETS family of transcription factors, characterized by a central DNA-binding ETS domain. ELF4 regulates the transcription of genes vital for hematopoietic homeostasis, immune system development, cell differentiation, and cell cycle progression. It is expressed in normal hematopoietic tissue, ovary, placenta, colon, and certain cancer cell lines. ELF4 functions as both a **tumor suppressor** and an oncogene, depending on cellular context, and plays a critical role in cancer metastasis, proliferation, and immune regulation. Its activity is modulated by post-translational modifications, gene fusions, and cellular signaling networks. ELF4 also participates in pathways controlling apoptosis and DNA damage responses, interacting with proteins such as p53, MDM2, RUNX1, and RUNX2. Clinical research highlights ELF4’s potential as both a biomarker and a target for therapeutic intervention.

Other names

ETS-related transcription factor Elf-4ELF4MEF (Myeloid Elf-1-like factor)ELFRE74-like factor 4Myeloid Elf-1-like factorAIFBL2E74 like ETS transcription factor 4

Drugs targeting ELF4 would likely function by **modulating gene transcription** through ELF4’s DNA-binding activity or by interfering with its protein-protein interactions (e.g., with RUNX1, RUNX2, MDM2). Potential modulations: suppression/activation of transcriptional output in cancer or immune cells. Antagonists of ELF4 could indirectly affect the cell cycle, apoptosis, immune activation, or differentiation.