E74-like ETS transcription factor 4 (ELF4) (ELF4)

E74-like ETS transcription factor 4 (ELF4), also known as Myeloid Elf-1-like factor (MEF), is a member of the ETS family of transcription factors that regulates gene expression by binding to specific DNA sequences. It is a key regulator of the cell cycle, particularly the G1/S transition, and is vital for the development and function of immune cells such as natural killer (NK) and T cells. ELF4 also plays a significant role in maintaining hematopoietic stem cell quiescence and modulating the innate immune response through the induction of type I interferons. In human disease, ELF4 is frequently dysregulated; it is overexpressed in several malignancies, including glioma, colorectal cancer, and leukemia, where it promotes tumor growth, metastasis, and resistance to therapy. Conversely, it can act as a tumor suppressor in certain epithelial contexts, highlighting its complex, context-dependent role in carcinogenesis. Although direct pharmacological inhibitors of ELF4 are not yet clinically available, it is an active area of research for targeted cancer therapies and immunomodulation.

Other names

Myeloid Elf-1-like factorMEFE74-like factor 4ETS-related transcription factor Elf-4

Transcriptional modulation of target genes involved in cell cycle progression and immune cell development